Grazia Aleppo, MD, FACE's portrait

Grazia Aleppo, MD, FACE

Associate Professor in Medicine-Endocrinology
Northwestern University
Chicago, IL
Dr. Aleppo is a member of the OnTrack Diabetes Editorial Board.

About Grazia Aleppo, MD, FACE

Grazia Aleppo, MD, FACE is a Clinical Practice Director, Glucose Management Service Director, Assistant Professor of Medicine, and Associate Chief for Clinical Affairs in the Division of Endocrinology, Metabolism, and Molecular Medicine at Northwestern University in Chicago.

Dr. Aleppo currently teaches in both the internal medicine residency program and endocrinology fellowship program at Northwestern University’s Feinberg School of Medicine.

She is a fellow of the American College of Endocrinology and member of several organizations, including the Endocrine Society, the American Association of Clinical Endocrinologists (AACE), and the American Diabetes Association (ADA).She has been accredited in thyroid ultrasound and ultrasound-guided fine needle aspiration (FNA) biopsy by the AACE.

She earned her physician and surgeon degree (MD) from the University of Catania, School of Medicine, in Catania, Italy, and completed her endocrinology fellowship at the University of Illinois at Chicago.



Canonico PL, Aronica E, Bruno V, Catania MV, Aleppo G, Galavotti F, Nicoletti F. Pyrrolidonecarboxylic acid magnesium salt (PCA-Mg2+) protects against seizures induced by excitatory amino acids. Functional Neurol. 1990; 5:121-126.
Canonico PL, Aronica E, Aleppo G,Casabona G, Copani A, Favit A, Nicoletti F, Scapagnini U. Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats. Functional Neurol. 1991;6:2:107-111.
Rampello L, Giammona G, Aleppo G,Favit A, Fiore L. Trophic action of Acetyl-L-Carnitine in neuronal cultures. Acta Neurol. 1992;14:1:15-21.
Copani A, Genazzani G, Aleppo G,Canonico PL, Scapagnini U, Nicoletti F. Nootropic drugs positively modulate AMPA-sensitive glutamate receptors in neuronal cultures. J Neurochem. 1992; 58:4:1199-1204.
Sortino MA, Aleppo G, Scapagnini U, Canonico PL. Ipriflavone inhibits phosphoinositide hydrolysis and calcium uptake in the osteoblast-like UMR-106 cells. Eur J Pharmacol. 1992;226:273-277.
Aleppo G,Pisani A, Copani A, Bruno V, Aronica E, D'Agata V, Canonico PL, Nicoletti F. Metabotropic glutamate receptors and neuronal toxicity. Adv Exp Med Biol. 1992;318:137-145.
Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Parathyroid hormone and arachidonate metabolism. J Endocrinology Invest. 1992;9:27-34.
Canonico PL, Nicoletti F, Sortino MA, Aleppo G, Scapagnini U. Effect of CDP-choline administration on receptor-stimulated inositol phospholipid hydrolysis in brain slices and neuronal cultures. Functional Neurol. 1992;7:275-281.
Nicoletti F, Casabona G, Genazzani AA, Copani A, Aleppo G, Canonico PL, Scapagnini U. Excitatory amino acids and neuronal plasticity: modulation of AMPA receptors as a novel substrate for the action of nootropic drugs. Functional Neurol. 1992;7:413-422.
Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Acetyl-L-carnitine prevents age-dependent neuroendocrine alterations of reproductive function. Life Sci Adv Exp Clin Endocrinol. 1992;11:101-116.
Di Stefano M, AleppoG, Casabona G, Genazzani AA, Scapagnini U, Nicoletti F. Amyloid beta-protein does not interact with tachykinin receptors coupled to inositol phospholipid hydrolysis in human astrocytoma cells. Brain Res. 1993;600:166-168.
Favit A, Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Protection by dihydroergocryptine of glutamate-induced neurotoxicity. Pharmacol Toxicol. 1993;73:224-228.
Giraldi FP, Mizobuchi M, Horowitz ZD, Downs TR, Aleppo G, Kier A, Wagner T, Yun JS, Kopchick JJ, Frohman LA. Development of neuropithelial tumors of the adrenal medulla in transgenic mice expressing a mouse hypothalamic growth hormone-releasing hormone promoter-simian virus-40 T-antigen fusion gene. Endocrinology. 1994;134:1219-1224.
Sortino MA, Aleppo G,Scapagnini U, Canonico PL. Involvement of nitric oxide in the regulation of gonadotropin-releasing hormone from the GT1-1 neuronal cell line. Endocrinology. 1994;134:1782-1787.
Aleppo G,Nicoletti F, Sortino MA, Casabona G, Scapagnini U, Canonico PL. Chronic L-alpha-Glyceryl-phosphoryl-choline increases inositol phosphate formation in brain slices and neuronal cultures. Pharmacol Toxicol. 1994;74: 95-100.
Aleppo G,Sortino MA, Scapagnini U, Canonico PL. Modulation of hypothalamic protein kinase C activity by alpha -glyceryl-phosphoryl-0-serine. Neuroendocrinol Lett. 1994;16:41-46.
Favit A, Sortino MA, Aleppo G,Scapagnini U, Canonico PL. The inhibition of peroxide formation as a possible substrate for the neuroprotective action of dihydroergocryptine. J Neural Transm. 1994;45: (suppl) 297-305.
Sortino MA, AleppoG, Scapagnini U, Canonico PL. Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging. Brain Res. 1996;41:359-362.
Sortino MA, Aleppo G, Copani A, Casabona G, Nicoletti F, Betra C, Kuhn R, Knoepfel T, Malischek B, Canonico PL. Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cAMP formation. Eur J Neurosci. 1996;8:2407-2415.
Kineman RD, Aleppo G,Frohman LA. The tyrosine hydroxylase-human growth hormone (GH) transgenic mouse as a model of hypothalamic GH deficiency: growth retardation is the result of a selective reduction in somatotrope numbers despite normal somatotrope function. Endocrinology. 1996;137:4630-4636.
Aleppo G, Moskal SF, DeGrandis P, Kineman RD, Frohman LA. Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels. Endocrinology. 1997;13:8:1058-1065.
Aleppo G,Copani A, Pisani A, Ratti E, Canonico PL, Nicoletti F. Eccitotossine ambientali e malattie neurodegenerative: studio del meccanismo d'azione della N-metil-beta-amino-L-alanina (BMAA). In: "Ambiente e malattie del Sistema Nervoso", Atti del Primo Congresso Nazionale "Ambiente e Malattie del Sistema Nervoso". Meco G, Bonifati V (eds). Edigraf Srl. 1991:29-34.
Aleppo G,Nicoletti F, Sortino MA, Pisani A, Scapagnini U, Canonico PL. La Neuroprotezione. In: "Vascolare verso metabolico", Atti del Terzo Workshop “La neurosenescenza”. Agnoli A, Scapagnini U, Zanussi C, (eds). Excerpta Medica. Amsterdam, 1992.
Case reports
De Bustros A, Aleppo G, Zikos D. Hypokalemia in Pregnancy: a clue to Gitelman’s syndrome. The Endocrinologist. 2001;11:6:447-450.
Patel V, De Bustros A, Aleppo G. Acute exacerbation of Diabetes and Hypothyroidism in a patient with hepatitis C after therapy with interferon Alpha. The Endocrinologist. 2007;17:157-159.
Valerio F, Sierra M, Duey D, Aleppo G, Tulley J and de Bustros, A. Glycemic control in the medical intensive care unit achieved by implementing a “user friendly” insulin infusion protocol. ACP Illinois Chapter, Chicago, IL, 2004.
Agarwal M, Agarwal G, Aleppo G.Brown tumor as the first manifestation of primary hyperparathyroidism. Endocr Pract. 2006;12:2:90.

Articles Written by Grazia Aleppo, MD, FACE

Gestational Diabetes Overview

Gestational diabetes is diabetes during pregnancy. Learn how eating well, exercising, and taking medications may help you protect your baby.

Type 2 Diabetes: Causes, Symptoms, and Diagnosis

Type 2 diabetes is the more common form of diabetes, and it used to be called adult-onset diabetes or non-insulin-dependent diabetes. Learn about the causes, symptoms, and diagnosis for type 2 diabetes.

What Is Type 2 Diabetes?

Plus, what causes Type 2 Diabetes

Type 1 Diabetes Treatments

Insulin, Blood Glucose Monitoring, Diet, and Exercise
Type 1 diabetes treatments are all about your blood glucose levels—keeping them in your goal ranges. Insulin, blood glucose monitoring, diet, and exercise all work together to keep you healthy and to help prevent long-term diabetes complications.

Type 1 Diabetes: Causes, Symptoms, and Diagnosis

Type 1 diabetes used to be called juvenile diabetes or insulin-dependent diabetes. Article explains causes, symptoms, and diagnosis of type 1 diabetes.

Controlling Diabetes Now May Prevent Dementia Later

Patients with diabetes are at increased risk of developing dementia--but early treatment and good blood glucose control can help stem the tide.

6 Things You Can Do To Improve Memory

Here are 6 ways to help you improve your memory and decrease your risk of developing dementia.

Articles Reviewed by Grazia Aleppo, MD, FACE

FDA Approves First Hybrid Artificial Pancreas

Medtronic's MiniMed670G should be on the market by Spring 2017
A brand-new “artificial pancreas,” the Medtronic MiniMed670G, that automatically checks glucose levels and delivers customized insulin doses to people with type 1 diabetes has won FDA approval.

Dexcom Recall: Continuous Glucose Monitor Alarms May Not Work

Dexcom, Inc., a major US maker of continuous glucose monitoring systems (CGMs), is urging users of its G4 Platinum and G5 Mobile CGM systems to test their units and contact the company immediately if alarms for low and high blood sugar levels aren’t functioning. The company announced a voluntary recall of the receivers after consumers complained about the problem.1

Am I at Risk of Developing Cancer?

Doctors are searching for an answer to the question: Does diabetes increase someone's risk for cancer?
People with both Type 1 and Type 2 diabetes appear to be at higher risk of developing certain types of cancer—but as to why it exists, there is still some dispute.1

First Stem-cell Implant for Type 1 Diabetes

Islet encapsulated cell was implanted into patient. Study will evaluate the safety and efficacy of the therapy—a potential replacement source of insulin-producing cells.
First stem cell transplant to combat type 1 diabetes.

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Author's Statement

I, or an immediate family member, have a financial interest(s) or affiliation(s) with the following commercial companies whose products and / or services may be mentioned in the materials I have authored, edited or reviewed for presentation on Remedy Health Media, LLC’s websites.

Disclosed Relationships